We aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart\ndisease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine. We enrolled 1178\nhospitalized T2DM patients. The patients were divided into a lower extremity PAD group (ankle-brachial index ââ?°Â¤ 0 9 or\n>1.4; 88 patients, 7.5%) and a non-PAD group (ankle-brachial index > 0 9 and ââ?°Â¤1.4; 1090 patients, 92.5%). Age;\nduration of diabetes; systolic blood pressure; the hypertension rate; the use of hypertension drugs, ACEI /ARB, and\nstatins; CHD risk; fatal CHD risk; stroke risk; and fatal stroke risk were significantly higher in the PAD group than in\nthe non-PAD group (P < 0 05 for all). Logistic stepwise regression analysis indicated that ABI was an independent\npredictor of 10-year CHD and stroke risks in T2DM patients. Compared with those in the T2DM non-PAD group, the odds\nratios (ORs) for CHD and stroke risk were 3.6 (95% confidence interval (CI), 2.2ââ?¬â??6.0; P < 0 001) and 6.9 (95% CI, 4.0ââ?¬â??11.8;\nP < 0 001) in those with lower extremity PAD, respectively. In conclusion, lower extremity PAD increased coronary heart\ndisease and stroke risks in T2DM.
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